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Case Report

Thyroid carcino-sarcoma in a dog

Antonio Giuliano, Jessica Grant, Jerome Benoit
Journal of the South African Veterinary Association | Vol 84, No 1 | a120 | DOI: https://doi.org/10.4102/jsava.v84i1.120 | © 2013 Antonio Giuliano, Jessica Grant, Jerome Benoit | This work is licensed under CC Attribution 4.0
Submitted: 07 May 2012 | Published: 12 April 2013

About the author(s)

Antonio Giuliano, Veterinary Referral Cancer and Critical Care, Laindon, United Kingdom
Jessica Grant, Veterinary Referral Cancer and Critical Care, Laindon, United Kingdom
Jerome Benoit, Veterinary Referral Cancer and Critical Care, Laindon, United Kingdom


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Abstract

An adult male greyhound was diagnosed with a thyroid carcino-sarcoma by means of histopathology and positive immuno-histochemistry staining for cytokeratin and vimentin. Surgery and radiotherapy of the area were successful in local tumour control. Adjuvant chemotherapy was recommended to treat and prevent further metastasis. The use of carboplatin, metronomic cyclophosphamide chemotherapy and toceranib failed to control the progression of distant metastasis. The survival time was seven months from the time of diagnosis. This is the eighth case of carcino-sarcoma of the thyroid documented in veterinary medicine and the first one treated with a multimodal approach based on surgery, radiotherapy and chemotherapy. As documented in human medicine, chemotherapy appeared to be ineffective to prevent or delay the progression of the metastatic disease in this case.


Keywords

carcinosarcoma, thyroid, carboplatin, radiotherapy, metronomic chemotherapy.

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Crossref Citations

1. Thyroid haemangiosarcoma in a seven‐year‐old female Shih Tzu
Luis Pedro Rocha Moreira, Emma Scurrell, Paul Mahoney, Stephen Baines
Veterinary Record Case Reports  vol: 8  issue: 2  year: 2020  
doi: 10.1136/vetreccr-2019-001012