Original Research

Blood acid–base, haematological and haemostatic effects of hydroxyethyl starch (130/0.4) compared to succinylated gelatin colloid infusions in normovolaemic dogs

Roxanne K. Buck, Lynette Bester, Keagan J. Boustead, Abdur R. Kadwa, Gareth E. Zeiler
Journal of the South African Veterinary Association | Vol 91 | a1990 | DOI: https://doi.org/10.4102/jsava.v91i0.1990 | © 2020 Roxanne K. Buck, Lynette Bester, Keagan J. Boustead, Abdur R. Kadwa, Gareth E. Zeiler | This work is licensed under CC Attribution 4.0
Submitted: 13 June 2019 | Published: 04 June 2020

About the author(s)

Roxanne K. Buck, Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa
Lynette Bester, Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa; and, Companion Animal Health Centre, School of Animal and Veterinary Science, University of Adelaide, Adelaide, Australia
Keagan J. Boustead, Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa; and, Section of Anaesthesia and Critical Care, Valley Farm Animal Hospital, Pretoria, South Africa
Abdur R. Kadwa, Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa
Gareth E. Zeiler, Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa; and, Section of Anaesthesia and Critical Care, Valley Farm Animal Hospital, Pretoria, South Africa


Share this article

Bookmark and Share

Abstract

Synthetic colloids are commonly administered to dogs to treat absolute or relative hypovolaemia. Voluven® (tetrastarch 130/0.4) and Gelofusine® (succinylated gelatin) are available to veterinarians in South Africa. In humans, use of these products has caused acid–base derangements, changes in haematology and impaired haemostasis. We aimed to investigate these effects in healthy normovolaemic dogs. Eight healthy adult beagle dogs underwent a cross-over study, receiving Voluven® or Gelofusine® (10 mL/kg/h for 120 min) once each with a 14-day washout between treatments. Dogs were premedicated with dexmedetomidine (10 µg/kg intramuscularly). Anaesthesia was induced with propofol and the dogs were maintained with isoflurane-in-oxygen. The anaesthetised dogs were connected to a multi-parameter monitor to monitor physiological parameters throughout. Catheters placed in a jugular vein and dorsal metatarsal artery allowed sampling of venous and arterial blood. Blood was collected immediately prior to commencement of colloid infusion, after 60 min infusion and at the end of infusion (120 min) to allow for arterial blood gas analysis, haematology and coagulation testing (activated partial thromboplastin time [aPTT], prothrombin time [PT] and thromboelastography [TEG]). There was no effect, between treatments or over time, on blood pH. The haemoglobin concentration, erythrocyte count and haematocrit decreased significantly over time (all p < 0.01), with no differences between treatments, and remained within normal clinical ranges. There were no differences between treatments or over time for the TEG, aPTT and PT tests of haemostasis. At the dose studied, Voluven® and Gelofusine® had comparably negligible effects on blood acid–base balance and coagulation in normovolaemic dogs.

Keywords

acid–base balance; coagulation; Gelofusine; synthetic colloids; Voluven; full blood count (FBC); complete blood count (CBC)

Metrics

Total abstract views: 206
Total article views: 174


Crossref Citations

No related citations found.