Case Report

Superficial angiomyxoma in a pregnant cow

Annalisa Rizzo, Leonardo Della Salda, Mariarita Romanucci, Stefano Ciccarelli, Carmela Valastro, Michela Galgano, Raffaele L. Sciorsci
Journal of the South African Veterinary Association | Vol 91 | a2004 | DOI: https://doi.org/10.4102/jsava.v91i0.2004 | © 2020 Annalisa Rizzo, Leonardo Della Salda, Mariarita Romanucci, Stefano Ciccarelli, Carmela Valastro, Michela Galgano, Raffaele L. Sciorsci | This work is licensed under CC Attribution 4.0
Submitted: 26 July 2019 | Published: 16 July 2020

About the author(s)

Annalisa Rizzo, Department of Veterinary Medicine, University of Bari Aldo Moro, Bari, Italy
Leonardo Della Salda, Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy
Mariarita Romanucci, Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy
Stefano Ciccarelli, Department of Veterinary Medicine, University of Bari Aldo Moro, Bari, Italy
Carmela Valastro, Department of Veterinary Medicine, University of Bari Aldo Moro, Bari, Italy
Michela Galgano, Department of Veterinary Medicine, University of Bari Aldo Moro, Bari, Italy
Raffaele L. Sciorsci, Department of Veterinary Medicine, University of Bari Aldo Moro, Bari, Italy


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Abstract

A 3-year-old, pregnant, Alpine Brown cow showed a rapidly growing, pedunculated, skin mass located at the umbilical region, reaching 8 kg in weight over a 3-month period after its initial detection. Six days after parturition, the mass was completely surgically excised. During the follow-up period, the cow remained in good health, without signs of recurrence, and showed increased milk production. Histological examination of the mass revealed a loose proliferation of spindle-shaped or stellate cells, immersed in an abundant myxoid matrix with admixed numerous thin-walled blood vessels. Immunohistochemically, the tumour cells were positive for vimentin, α-smooth muscle actin, and desmin. Gross and histopathological features were compatible with superficial angiomyxoma, a subtype of angiomyxoma rarely described in humans, but not in the veterinary literature. The tumour did not infiltrate into the surrounding tissues, and there was no post-excision recurrence after 3 months. The possibility of hormonal dependence of the tumour during pregnancy is discussed based on such findings in some human cases.

Keywords

angiomyxoma; cow; cutaneous; histopathology; hormone dependency; immunohistochemistry; pregnancy

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