Pharmacokinetics, urinary excretion and plasma protein binding of ofloxacin in water buffalo calves (Bubalus bubalis)

Authors

  • Ajay K Ola Guru Angad Dev Veterinary and Animal Sciences University
  • Harpal S Sandhu Guru Angad Dev Veterinary and Animal Sciences University
  • Vinod K Dumka Guru Angad Dev Veterinary and Animal Sciences University
  • Bibhuti Ranjan Guru Angad Dev Veterinary and Animal Sciences University

Abstract

Pharmacokinetics and urinary excretion of an intravenous dose of 5 mg.kg–1 ofloxacin were investigated in water buffalo calves. Plasma concentrations of ofloxacin were determined by high-performance liquid chromatography. Ofloxacin was rapidly distributed from the central to the peripheral compartment as evidenced by a short distribution half-life (0.09 h ± 0.003 h) and high K12 (4.7 h–1 ± 0.1 h–1), and was detected in plasma for 8 h. The large volume of distribution (2.48 L.kg–1 ± 0.18 L.kg–1) obtained in this study indicated high distribution of ofloxacin in water buffalo calves. The elimination half-life, the area under
the plasma drug concentration–time curve and total body clearance were 2.11 h ± 0.13 h, 6.20 mg.mL—1 ± 0.23 mg.mL—1.h and 0.81 mL.kg–1.h–1 ± 0.03 mL.kg–1.h–1, respectively. About 18.7% of administered drug was bound to plasma proteins and approximately 32.5% of the administered dose was recovered in urine within 48 h. The results of the study indicated a favourable pharmacokinetic profile of ofloxacin in water buffalo calves, which suggests that ofloxacin may be effective against urinary pathogens in this species.

Author Biographies

  • Ajay K Ola, Guru Angad Dev Veterinary and Animal Sciences University

    Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, India

  • Harpal S Sandhu, Guru Angad Dev Veterinary and Animal Sciences University

    Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, India

  • Vinod K Dumka, Guru Angad Dev Veterinary and Animal Sciences University

    Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, India

  • Bibhuti Ranjan, Guru Angad Dev Veterinary and Animal Sciences University

    Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, India

Downloads

Published

2021-12-06

Issue

Section

Original Research