Canine multi-drug resistance-1 mutation prevalence: A South African perspective

Authors

  • Lérica le Roux-Pullen University of Pretoria
  • Henriëtte van der Zwan Inqaba Biotechnical Industries (Pty) Ltd

Abstract

The multi-drug resistance (mdr-1) gene mutation is a phenomenon well known to current veterinary practitioners. The mutation causes a predisposition for, amongst other phenomena, macrocyclic lactone-induced neurotoxicosis in affected canines, a condition that can be fatal. Various herding dog breeds can be heterozygous or homozygous for the mutation, and prevalence differs only slightly in dog populations between geographical regions. This report provides prevalence data of the canine mdr-1 mutation in 306 South African dogs.

Author Biographies

  • Lérica le Roux-Pullen, University of Pretoria

    Department of Paraclinical Sciences, University of Pretoria, South Africa

  • Henriëtte van der Zwan, Inqaba Biotechnical Industries (Pty) Ltd

    Inqaba Biotechnical Industries (Pty) Ltd, Pretoria, South Africa

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Published

2021-12-09

Issue

Section

Research Communication