Original Research

Toxicokinetics of cotyledoside following intravenous administration to sheep

C.J. Botha, T. Rundberget, G.E. Swan, M.S.G. Mulders, A. Flaoyen
Journal of the South African Veterinary Association | Vol 74, No 1 | a488 | DOI: https://doi.org/10.4102/jsava.v74i1.488 | © 2003 C.J. Botha, T. Rundberget, G.E. Swan, M.S.G. Mulders, A. Flaoyen | This work is licensed under CC Attribution 4.0
Submitted: 25 June 2003 | Published: 25 June 2003

About the author(s)

C.J. Botha,
T. Rundberget,
G.E. Swan,
M.S.G. Mulders,
A. Flaoyen,

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Abstract

Cotyledoside, a bufadienolide cardiac glycoside, was administered intravenously to sheep in 2 studies. In experiment 1, sheep (n = 4) received 0.0135 mg / kg daily on 5 consecutive days and in the 2nd experiment, sheep (n = 4) received 0.027 mg / kg as a single dose. Jugular blood was collected at different time intervals and kinetic parameters were determined. The data fitted a 1-compartmental model. In both experiments a short half-life (t1/2) and mean residence time (MRT), a relative small volume of distribution (Vdss) and rapid clearance were calculated. In the 1st experiment, t1/2 and MRT increased significantly (P < 0.007) from Day (D) 0 to D 4. It is suggested that the rapid decline in plasma cotyledoside concentrations in sheep denotes rapid distribution of cotyledoside to the tissues or extracellular spaces and possible accumulation at the biophase.

Keywords

Cardiac Glycoside; Cotyledoside; Kinetics; Krimpsiekte; Sheep

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