Original Research

Changes in respiratory function following the intramuscular administration of etorphine to boer goats (Capra hircus)

P.E. Buss, D.G.A. Meltzer
Journal of the South African Veterinary Association | Vol 72, No 3 | a636 | DOI: https://doi.org/10.4102/jsava.v72i3.636 | © 2001 P.E. Buss, D.G.A. Meltzer | This work is licensed under CC Attribution 4.0
Submitted: 09 July 2001 | Published: 09 July 2001

About the author(s)

P.E. Buss,
D.G.A. Meltzer,

Full Text:

PDF (75KB)

Share this article

Bookmark and Share

Abstract

The physiological effects on respiratory function of etorphine (M99, Logos Agvet) (30 µg/kg) administered intramuscularly were determined in boer goats. The goats were habituated to the experimental procedures so that respiratory function could be determined while the animals stood quietly at rest. This enabled the physiological changes induced by etorphine to be measured and compared with those obtained before administration of the immobilising drug. The effectiveness of diprenorphine (M5050, Logos Agvet) (3 mg/1 mg etorphine) as an antagonist of the physiological changes induced by the etorphine treatment was also determined. Etorphine depressed respiratory function, which resulted in a decrease in PaO2 and an increase in PaCO2. These changes were limited and occurred as a result of decreases in respiratory minute volume and alveolar minute ventilation caused by a decrease in respiratory rate. The physiological shunt fraction did not change significantly but there was a significant decrease in percentage physiological dead space ventilation. It was not possible to determine how effectively diprenorphine reversed the respiratory effects due to etorphine.

Keywords

Capra Hircus; Diprenorphine; Etorphine; Goats; Respiratory Function

Metrics

Total abstract views: 1830
Total article views: 2079

 

Crossref Citations

1. Ampakine CX1942 attenuates opioid-induced respiratory depression and corrects the hypoxaemic effects of etorphine in immobilized goats ( Capra hircus )
Anna J Haw, Leith CR Meyer, John J Greer, Andrea Fuller
Veterinary Anaesthesia and Analgesia  vol: 43  issue: 5  first page: 528  year: 2016  
doi: 10.1111/vaa.12358