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Von Willebrand's disease in the German shepherd dog : clinical communication

R.G. Lobetti, T. Dippenaar
Journal of the South African Veterinary Association | Vol 71, No 2 | a693 | DOI: | © 2000 R.G. Lobetti, T. Dippenaar | This work is licensed under CC Attribution 4.0
Submitted: 10 July 2000 | Published: 10 July 2000

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R.G. Lobetti,
T. Dippenaar,

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Two litters of Germanshepherd dogs were evaluated for a haemorrhagic tendency that was characterised by excessive bleeding from the umbilicus at birth, haemorrhage and haematoma formation at vaccination, excessive bruising, and lameness due to haemarthrosis. Platelet counts, clotting times and Von Willebrand's factor (VWF) assays were assessed in all dogs. Factor VIII determination was performed in 1 puppy and its parents. Based on the clotting times and VWF assay, 6 puppies (4 male and 2 female) showed type I Von Willebrand's disease (VWD), 5 (4 male and 1 female) possible type II VWD, and 4 were unaffected. One puppy with possible type II VWD had very low factor VIII activity; its sire had a normal factor activity, whereas the dam was in the low-normal range. This article reports type I and possible type II VWD in 2 related litters of German shepherd dogs, the latter being rare in German shepherd dogs.


Factor VIII; German Shepherd Dogs; Haemorrhagic Tendency; Von Willebrand’s Disease; Von Willebrand’s Factor Assay


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1. A review of hereditary diseases of the German shepherd dog
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doi: 10.1016/j.jveb.2008.05.004