Original Research

An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy

B. Nevill, A. Leisewitz, A. Goddard, P. Thompson
Journal of the South African Veterinary Association | Vol 81, No 1 | a90 | DOI: https://doi.org/10.4102/jsava.v81i1.90 | © 2010 B. Nevill, A. Leisewitz, A. Goddard, P. Thompson | This work is licensed under CC Attribution 4.0
Submitted: 03 May 2010 | Published: 03 May 2010

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B. Nevill,
A. Leisewitz,
A. Goddard,
P. Thompson,

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The extent of trauma in a patient can be difficult for a clinician to quantify. A prospective study was performed on 2 groups of dogs undergoing either ovariohysterectomy or hemilaminectomy. The serum activity of creatine kinase and serum concentration of C-reactive protein were evaluated preoperatively and then at 4, 6, 8, 12, 24 and 48 hours postoperatively in both groups. The results were compared statistically both within and between the 2 groups. A wide range of results was found at each time point for both analytes although there were no significant differences for either analyte between the 2 surgical groups preoperatively. Thereafter there were significant differences in creatine kinase activity levels between the 2 groups. C-reactive protein concentration results were very similar in the 2 groups with no statistical difference at any time point. The results of this study suggest that the evaluation of CK and CRP at any one time point in a traumatised animal is of limited value. However, the evaluation of the trend of these 2 analytes, even over a relatively short time period, may allow for useful prognostication in clinical cases.


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